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While daily administration is possible , most protocols recommend 5-6 days per week with 1-2 rest days

Clin Cancer Res 17:63896397 ten Cate B, Bremer E, de Bruyn M, Bijma T, Samplonius D, Schwemmlein M, Huls G, Fey G, Helfrich W (2009) A novel AML-selective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability

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When cytoplasmic catecholamine concentrations rise to levels that threaten to saturate both VMAT2 sequestration and mitochondrial monoamine oxidase (MAO) degradation pathways, the reversal of plasma membrane transporters provides a vital escape route (Underhill et al., 2021)

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